top of page

What Is Kambo?

Kambo is a powerful detoxification ritual first used by ancient Amazonian Tribes. It is shown to increase the body’s natural ability to heal itself by eliminating toxins through the lymphatic system and fortifies the immune system.

Kambo comes from the waxy secretion of the Phyllomedusa Bicolor, the Giant Monkey Tree Frog found 

in the rainforests of the upper Amazon.


The secretion is applied through superficial burns made into the skin. The immediate effects of Kambo bring on nausea, vomiting, diarrhea, sweating, light-headedness and other symptoms, but afterwards users report amazing health improvements for a variety of conditions, both physical and spiritual. 

The secretion is not sweat, nor a poison in the sense that it alone is not capable of causing death or illness. In the Amazon it is called “The Vaccine of the Jungle”, where the natives use it to gain strength, immunity, cure illnesses, to sharpen hunting skills, and also to get rid of “panema” which is dark, negative or stuck energy.

Kambo can bring a shift and deep healing by connecting to your authentic self and detoxing your mind, body and soul. It is one of the world’s most effective and natural antibiotics and an immune system booster. 

Kambo is legal in the United States and is not hallucinogenic. Kambo is very safe when given by a properly trained practitioner.


The effects of Kambo can be felt within the

Mind, Body & Spirit

the wholeness that is you.


Kambo has no known detrimental side effects, but when it is responsibly administered, it is completely safe. 


There are some people who should not take it; generally, it is not for you if you have, or have had in the past, any of the following conditions (This is not an exhaustive list):

  • Heart bypass surgery

  • Enlarged heart or Implanted cardioverter defibrillators

  • Congestive heart disease

  • Excess fluid in the heart sack

  • Heart valve replacement surgery

  • Organ transplant

  • Active ulcers

  • Addison’s Disease

  • Crohn’s Disease/Irritable Bowel Syndrome (IBS)

  • Brain hemorrhage

  • Blood clots

  • Serious mental health conditions, excluding depression, PTSD and anxiety

  • Lack the mental capacity to decide to take Kambo

  • Seriously low blood pressure that requires medication

  • Anyone recovering from a major surgical procedure

  • Pregnant or breastfeeding women with babies under 1-year old

  • Within 21 days of giving birth

  • Under 18 years of age

  • Chemotherapy or radiation treatments of less than 6 weeks prior or 6 weeks afterward

  • History of head trauma, or aneurysm

  • Esophageal vacries

  • If you are asthmatic, be sure to bring your inhaler with you

  • Diabetics need to bring insulin, testing strips, and food


Kambo Benefits

Kambo peptides, and their effects are reported to cover a wide range of potential benefits for those suffering from the following:​

  • Alzheimer's Disease

  • Cancer

  • HIV

  • Strokes

  • Lyme Disease

  • Herpes

  • Chronic Pain

  • Hepatitis 

  • Diabetes

  • Depression / Anxiety

  • Arthritis

  • Addiction

  • Chronic Fatigue

  • Parkinson's Disease

  • Vascular Disease

  • Rheumatism

The short-term benefits from Kambo can be enhanced resistance to tiredness, hunger, and thirst, an enhanced state of alertness, capacity to focus and still the mind. These effects can last for days or weeks.

Long-term, Kambo will strengthen and empower the immune system, help overcome fatigue and increase overall well-being. People that regularly take Kambo very rarely get sick and benefit from increased energy. 


Often, after people work with Kambo, they see massive energetic shifts in their lives. From dramatic improvements to their physical health including reductions in depression and addiction, to relief from chronic pain and other major illnesses.


The Experience

The waxy secretion is applied to the skin after small superficial burns are made with a red-hot ember vine stick (similar to incense) this is known as “The burning gates”.  Only the top layer of the skin is gently burned.


The number of gates used depends on the number of times that the person has already received Kambo, the reason for the application, physical condition, and overall assessment.

Once the Kambo is applied to the skin, it enters the body via the lymphatic system.  A feeling of warmth will immediately follow.


The face, skin, and core of the body will feel heat within. The heart will beat slightly faster. Blood pressure will fall slightly.


Relax into the experience. I will be with you throughout the entire time.

It is helpful to work with the breath: Inhale with love and trust, exhale and surrender. It is a common experience that the throat will gently swell. This is normal. It will not swell shut. The face may also swell. 


Simply relax into the sensations and allow the ally of the Kambo Spirit to purify and fortify you. 

After a few minutes or more, you may feel like you have to purge. You will have a bucket handy and you will purge into the bucket. You may also need to go to the bathroom. You will be assisted if needed to do so.


After your final purge, the Kambo points will be removed from your body and the major part of your cleanse is over.

The time spent at the peak of the cleansing and purgative process can be as short as 10 minutes or as long as a few hours.


Kambo is a very physical experience that involves a feeling of heat in the body and will be followed by vomiting and sometimes evacuating from the intestines as the body purges toxins from the various organs.

During this time, the mind often becomes clear and focused and some say they receive specific messages on a spiritual level.


Kambo works mostly to purge the body of toxins, heaviness, and dullness of body and spirit.


The benefits that many reports usually come in the days and weeks that follow. Many people report feeling very peaceful immediately after receiving Kambo and often the next day one feels amazing.


On a spiritual level, Kambo helps to integrate our mind with our heart
and realign our chakras.  

Scientific Research

Scientific studies show that Kambo is made up of many peptides that are beneficial to the human body. Some of these peptides traverse the blood-brain barrier and stimulate the endocrine glands of the brain, resulting in an immune effect and a deep cleansing of the body.


Examples of naturally occurring peptides in the human body include oxytocin, endorphin and insulin. Such amino acids are often referred to as the building blocks of all human life.

Kambo has antibiotic properties and strengthens the immune system, while physically destroying pathogenic microorganisms. Kambo is traditionally known to be anti-inflammatory, to relieve joint pain, to heal eyesight, and to ease pain.


What are peptides and how do they work?

Peptides are chains of amino acids, much like proteins. The main difference between the two is the length of those chains: peptides are short chains of amino acids and proteins are long chains of amino acids.


Peptides bind to receptor sites on the outer surface of biological cells, and this binding serves a variety of functions in the body and brain. Often they act as a form of message or signal, causing the cell to change what it’s doing. For example to manufacture and release more of a particular hormone or neurotransmitter, or the opposite. In this way, they can influence a variety of biological processes, ranging from moods and thought patterns in the brain to muscle contractions and digestion in the body.

So, what's in it?

Kambo contains a number of active compounds (which are all peptides):


Phyllomedusin - Phyllomedusin is a peptide of the Tachykinin family. It has a powerful effect on the intestine, bowels, salivary glands and tear ducts and stimulates a deep cleansing of the whole digestive system. It causes a contraction of the smooth muscle in the gut and plays a role in the emetic effect of Kambo application - the vomiting and purging that occurs during a Kambo ceremony.

Phyllomedusin works together with Phyllokinin, which is discussed below, to cause the contraction and relaxation of muscles associated with these gut contractions. Phyllomedusin is also a potent vasodilator and contributes to the lowering of blood pressure.

Phyllokinin - Phyllokinin is a peptide of the Bradykinin family. Similar to Phyllomedusin it also acts as a potent vasodilator and causes contraction of the smooth muscle of the gut. Phyllokinin also contributes to a reduction in blood pressure and increases vascular permeability.

There is a popular theory that Phyllokinin and Phyllomedusin may increase the permeability of the blood-brain barrier, enhancing the ability of the other Kambo peptides to quickly enter the brain, however, there has been no scientific research to back up this claim.


Phyllocarulein and Sauvagine - Both Phyllocarulein and Sauvagine are potent stimulators of gastric and pancreatic secretions which contribute to the early symptoms of nausea and vomiting present during a Kambo process. Both cause a drop in blood pressure accompanied by tachycardia (increased heart rate) and stimulate the adrenal cortex and pituitary gland, helping to increase sensory perception and increase physical endurance.


They also possess a great analgesic power, contributing to the increase of physical strength, the capacity to confront physical pain, stress, disease and diminish the symptoms of fatigue. Interestingly, Phyllocaerulein is present in the highest concentration of all the peptides and plays a part in modulating satiety, contributes to digestive improvement, modifies sedation and affects thermoregulation, potentially leading to profuse sweating during the experience.


Sauvagine functions like a hormone, interacting with the pituitary-adrenal axis and corticotropin-releasing receptors, which are involved in cortisol, stress, anxiety, depression, and addictive behaviors. It also holds properties that affect smooth muscle contraction of the colon and urinary bladder, alongside tachycardia and a reduction in blood pressure.

Adenoregulin aka Dermaseptin B2 - Dermaseptins including Adenoregulin form part of a family of a broad spectrum of antimicrobial peptides involved in the defense of the frogs’ bare skin against microbial invasion. In laboratory settings, it has been proven that Adenoregulin has both the ability to inhibit different forms of cancer and to restore healthily blood vessel growth. Despite the potent anti-cancer and antibacterial action of this peptide, it appears to be non-toxic to healthy human and animal cells.

Deltorphin - helps to relieve pain and instils a sense of calm through its action on opioid receptors. Can have a positive influence on the addictive conditions of those with opiate dependence.

Dermorphin - also acts on opioid receptors, in concert with Deltorphins, reducing the experience of pain and moderating mood. Again, acts similarly to Deltorphin in helping to alleviate some of the symptoms and issues associated with opiate dependence.

Litorin, Phyllolitorin, Rohdei-Litorin, “Leu”-phyllolitorin - 4 neuropeptides that stimulate gastric acid and pancreatic secretion and smooth muscle contraction.


In a paper by Caitlin Thompson and Martin L Williams, the following statement was made regarding Litorin: (

"Litorin has been observed in rats to decrease body temperature by 0.9 °C in the short term. It is possible that Phyllolitorins are responsible for the shivering commonly observed during the latter stages of the Kambô experience, as well as appetite suppression."

Antimicrobial and antiviral effects

Many of the peptides found in Kambo have antimicrobial and antiviral effects. Indeed, it is thought that one of the primary roles of the frog’s secretions is to act as a defensive shield for the frog’s skin against the invasion of various parasitic fungi and other microbes that would otherwise have a relatively easy time getting through and infecting the frog.


In more recent studies, many of these same peptides have been examined for use in treating otherwise problematic and drug-resistant bacteria and viruses that can play havoc with patients that have weakened immune systems - either as a result of their general health, or, particularly those with immunodeficiency disorders.


History of  Kambo

There is a Kaxinawá legend that says that the people of his village were very ill and the Shaman Kampu had tried everything possible to cure them. All medicinal herbs known were used, but none helped his people’s agony.

Kampu then entered the forest and under the effect of Ayahuasca, received the visit of the great God who brought in His hands a frog from which He took a white secretion.


He taught Kampu how to apply the secretion. When the Shaman Kampu returned to the tribe and followed the instructions he had received, he was able to cure his people.

After Shaman Kampu’s death, his spirit went to live in the frog and the Indians began to use its secretion to remain active and healthy.

– from Kambo, The Spirit of the Shaman.

bottom of page